Application of syndiotacticity‐rich PVA hydrogels to drug delivery system

Abstract

Abstract The preparation of stable syndiotacticity‐rich poly(vinyl alcohol) (s‐PVA) hydrogels is easier in comparison with that of the atactic poly(vinyl alcohol) (a‐PVA) hydrogels. The drug release with use of s‐PVA hydrogels containing indomethacin of 1.5 mg/mL buffer, solution was studied under several conditions: at the gelation temperatures of 20–30°C, the release temperatures of 27–47°C, and pHs of phosphate buffer solutions of 6.6–7.4, for the gels with the concentrations of PVA of 3–8% using the degree of polymerization of 2170–4380. Indomethacin has been released spending 14 h. The diffusion exponents were 0.45–0.50, corresponding to Fickian diffusion. © 1995 John Wiley & Sons, Inc.