FEBS Letters · 2007 · 43 citations · 27 references
MedicineMolecular BiologyOncologyGene ExpressionMetastasisMolecular OncologyCancer Cell SignalingHer2-positive Breast CancerMalignant NeoplasmsManganese MetabolismMetastatic Breast CancerReactive Oxygen SpeciesAnticancer ActivityAnticancer ChemotherapyHer2 ExpressionManganese EnzymesManganese Superoxide DismutaseOncogene Expression AnalysisSuperoxide Dismutase FunctionTransfection Reagents
The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185(HER2/neu). Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.
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Requirement for neuregulin receptor erbB2 in neural and cardiac development
Kuo-Fen Lee, Horst H. Simon, Hua Chen et al. · Nature · 1995 · 1.3K citations
Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts
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