Bioluminescent Probes of Sulfatase Activity

Abstract

Lighting up sulfatases: A panel of bioluminescent sulfatase reporters have been developed that can be used to investigate sulfatase activity in both human and prokaryotic cell samples. Structural modulation allowed selective probe activation by particular enzymes. This strategy has potential application in common clinical imaging modalities, such as MRI and PET. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.