Increased Esophageal Sensitivity to Acid and Saline in Patients With Nonerosive Gastro-esophageal Reflux Disease

Abstract

Both eGERD and NERD, but especially NERD, exhibited esophageal hypersensitivity not only to acid but also saline perfusion, suggesting that hyperalgesia to acid and other factors (eg, psychologic and/or autonomic nerve disturbance) may play some roles in symptom generation in NERD.