Chemotherapy · 2009 · 12 citations · 0 references
MedicineGynecologyPharmacokineticsAntimicrobial PharmacotherapyPerioperative Infection PreventionReproductive MedicineAntibiotic ProphylaxisAntimicrobial ProphylaxisGynecologic InfectionsIntraoperative Medication AdministrationSurgical Infection ManagementSurgical ProphylaxisAntibiotic Prophylaxis AdministrationAntibiotic Prophylaxis In SurgeryCeftriaxone TherapyIntraoperative ProphylaxisPerioperative Prophylactic AntibioticsSafe Intravenous InjectionSingle-dose ProphylaxisVaginal Hysterectomy
31 patients received an intravenous 15-min injection of 2 g ceftriaxone at various times before abdominal or vaginal hysterectomy. Ceftriaxone concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 20 micrograms/g could be maintained for at least 5 h. Due to its high tissue concentrations maintained for the whole operative procedure, ceftriaxone does seem to be one of the antibiotics of choice for single-dose prophylaxis of postoperative infections in gynecology.