Chromosome Abnormality in Rat Leukemia Induced by 7,12-Dimethylbenz[ <i>a</i> ]anthracene

Abstract

A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.