Science · 1982 · 2.9K citations · 15 references
Veterinary MedicineImmunologyInfectious DiseasesInfectious Disease PathologyMedical EntomologyVector-borne DiseasesLyme DiseaseTick BiologyTick-associated Skin DiseaseTick-borne DiseasesImmunofluorescence DiagnosisImmunofluorescence FindingsIndirect Immunofluorescence AssayIxodes Tick VectorsTick-associated Cutaneous LesionsTick-borne PathogensTick-borne TransmissionTick-borne Zoonoses
A treponema-like spirochete was detected in and isolated from adult Ixodes dammini, the incriminated tick vector of Lyme disease. Causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on New Zealand White rabbits 10 to 12 weeks after infected ticks fed on them. Samples of serum from patients with Lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. It is suggested that the newly discovered spirochete is involved in the etiology of Lyme disease.
15
Erythema Chronicum Migrans and Lyme Arthritis
Allen C. Steere, Malawista Se, Shaun Ruddy et al. · Annals of Internal Medicine · 1977 · 688 citations
Staining Rickettsiae in Yolk-Sac Cultures
Domingo F. Giménez · Stain Technology · 1964 · 629 citations