Hepatic stem‐like cells in hepatoblastoma: expression of cytokeratin 7, albumin and oval cell associated antigens detected by OV‐1 and OV‐6

Abstract

The results demonstrate that antigens associated with oval cells are found in certain cells in hepatoblastoma. SEC, like oval cells, co-express markers for hepatocytic and biliary differentiation. The findings further support the hypothesis that SEC are closely related to the putative bipotent hepatic stem cell, which, by definition, gives rise to both hepatocytes and biliary epithelial cells.