CP-91,243 and CP-91,244, novel diglycoside polyether antibiotics related to UK-58,852 and produced by mutants of Actinomadura roseorufa.

Abstract

Interest in polyether antibiotics has remained at a high level for over 20 years, owing largely to the commercial importance of this class of drugs in veterinary medicine. For example, monensin1*, lasalocid1} and salmomycin2) are marketed as anticoccidial agents for poultry, and are used as