A Rat Model of Otitis Media with Effusion Caused by Eustachian Tube Obstruction with and without <i>Streptococcus Pneumoniae</i> Infection: Methods and Disease Course

Abstract

The experimental methods provoked reproducible pathologic signs similar to those for otitis media with effusion. Given the availability of rat-specific reagents, this model is well suited for studies of cytokine elaboration during disease pathogenesis.