Intramolecular Migration of Coordinated Platinum(II) from the N7 Site to the Exocyclic Amino Group in 9-Methyladenine

Abstract

Treatment of trans-[Pt(NH3)2(9-madeH-N7)2](ClO4)4·2H2O (9-made = 9-methyladenine) under alkaline conditions results in the migration of the coordinated Pt(II) from the endocyclic N7 site to the exocyclic NH2 group, with a concomitant proton displacement, in one of the 9-made ligands to yield trans-[Pt(NH3)2(9-made-N6)(9-made-N7)](NO3)2·2H2O as colorless plates. The readiness of the migration reaction is strongly suggestive of an intramolecular N7 → N6 substitution, in which the N6 group acts as the nucleophile.