Synthesis and opioid activity of new fentanyl analogs

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Cyanohydridoborate anion as a selective reducing agent

Richard F. Borch, Mark D. Bernstein, H. D. Durst · Journal of the American Chemical Society · 1971 · 1.8K citations

Natural Sciences, Chemistry, Analytical Chemistry +5

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

Philip S. Portoghese, Marjia Sultana, A.E. Takemori · European Journal of Pharmacology · 1988 · 613 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

Philip S. Portoghese, A. W. Lipkowski, A.E. Takemori · Life Sciences · 1987 · 533 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Rabbit vas deferens: A specific bioassay for opioid κ-receptor agonists

Tetsuo Oka, Kazuko Negishi, Mitsuaki Suda et al. · European Journal of Pharmacology · 1981 · 180 citations

Medicine, Pharmacology, Experimental Pharmacology +15