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Synthesis of novel dispiropyrrolothiazoles by three-component 1,3-dipolar cycloaddition and evaluation of their antimycobacterial activity
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Citations
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References
2014
Year
Bioorganic ChemistryNovel DispiropyrrolothiazolesAntimicrobial ChemotherapyHeterocycle ChemistryAntimycobacterial ActivityPharmaceutical ChemistryMedicinal ChemistryAntimicrobial Drug DiscoveryBiochemistryDispiropyrrolothiazoles DerivativesAntibacterial AgentDft CalculationsAntimicrobial CompoundPharmacologyAntifungal AgentAntibioticsNatural SciencesCycloaddition ReactionMicrobiologyThree-component 1,3-Dipolar CycloadditionMedicineDrug Discovery
A series of dispiropyrrolothiazoles derivatives has been synthesized screened<italic>in vitro</italic>against<italic>Mycobacterium tuberculosis</italic>H37Rv. The observed regio- and stereoselectivity of the cycloaddition reaction has been rationalized by DFT calculations.
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