Lentiviral Vector-Mediated<i>PAX6</i>Overexpression Promotes Growth and Inhibits Apoptosis of Human Retinoblastoma Cells

Abstract

Lentiviral vector-mediated overexpression of PAX6 in human retinoblastoma cells was associated with increased cell proliferation parallel to a reduced caspase-3-dependent apoptotic rate and a change in the p53 regulated cell cycle. PAX6 may be further explored for the diagnosis of and therapy for retinoblastomas.