Highly Enantioselective Organocatalyzed Vinylogous Michael-Type Reaction for the Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters

Abstract

The first example of a highly enantioselective vinylogous Michael-type reaction of β,β-disubstituted nitroalkenes is disclosed. A series of biologically important chiral oxindoles, featuring a trifluoromethylated all-carbon quaternary chiral center, were obtained in good yields with excellent enantioselectivities (up to >99% ee).