VIII. EFFECT OF HYPOXIA AND POST‐HYPOXIC POLYCYTHAEMIA (REBOUND) ON MOUSE MARROW AND SPLEEN

Abstract

SUMMARY Quantitative marrow changes, 59 Fe incorporation into erythrocytes and spleen weight variations have been studied in mice during primary hypoxia and rebound. The pattern of the mouse response to hypoxia is similar to that already described in the guinea‐pig. The possible involvement of the lymphocyte in erythropoiesis whether as stem cell or otherwise is suggested by the fact that its accumulation in the marrow seems to be inversely related to erythropoietic activity. The effect of hypoxia on the stem cell compartment is discussed.