Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.

Jean Rossier, Therese Vargo, Susan Minick et al. · Proceedings of the National Academy of Sciences · 1977 · 454 citations · Full text

Medicine, Neurobiology, Neuroscience +13

EFFECTS OF CHANGES IN THE STRUCTURE OF ENKEPHALINS AND OF NARCOTIC ANALGESIC DRUGS ON THEIR INTERACTIONS WITH μ‐ AND δ‐RECEPTORS

H. W. Kosterlitz, John A.H. Lord, Sue Paterson et al. · British Journal of Pharmacology · 1980 · 316 citations · Full text

Medicine, Neurobiology, Pharmacology +17

Isolation of the opioid heptapeptide Met-enkephalin [Arg6,Phe7] from bovine adrenal medullary granules and striatum.

A S Stern, Randolph V. Lewis, Sadao Kimura et al. · Proceedings of the National Academy of Sciences · 1979 · 250 citations · Full text

Medicine, Neuroscience, Pharmacology +13