Spectrophotometric determination of chlorpheniramine maleate and chlor-phenoxamine hydrochloride each in presence of caffeine as binary mixtures.

Abstract

The dye-salt formation method was successfully applied to the determination of chlorpheniramine maleate and chlorphenoxamine hydrochloride each in presence of caffeine. At pH 5, the chromogens (λmax=420 nm) produced with methyl orange in chloroform obeyed Beer's law over the range 5-15 ug/ml and with relative SD less than 1%.