Haplotype analysis of a 100 kb region spanning TNF–LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan

Abstract

Our results suggest that LTA is one of the genes that contributes to susceptibility to atopic asthma, and that the association of the TNF/LTA haplotypes to asthma may be defined by the polymorphism in the LTA promoter region in the Japanese population.