<i>Escherichia coli</i> heat‐labile enterotoxin B subunit prevents autoimmune arthritis through induction of regulatory CD4+ T cells

Abstract

Mucosal administration of EtxB can be used to prevent or treat CIA. Modulation of the anti-CII immune response by EtxB is associated with a reduction in Th1 cell reactivity without a concomitant shift toward Th2. Instead, EtxB mediates its effects through enhancing the activity of a population of CD4+ regulatory T cells.