Inactivation of <i>Orientia tsutsugamushi</i> in red blood cells, plasma, and platelets with riboflavin and light, as demonstrated in an animal model

Abstract

Riboflavin and light are effective in reducing O. tsutsugamushi. Mice injected with blood products inoculated with 10(5) organisms and treated with riboflavin and light did not experience any signs or symptoms of infection, 17 days after inoculation. A 5-log reduction of this organism in blood was achieved as assayed in an animal model.