The histogenesis of carcinoma in situ of the uterine cervix.A preliminary report of the origin of carcinoma in situ in subcylindrical cell anaplasia

Abstract

and Martzlofflv gave evidence that invasive cervical cancer arose in a field of "surface carcinoma," (carcinoma in situ, preinvasive carcinoma, intraepithelial carcinoma). At the time, this was a revolutionary concept. Prior to these observations, there was a common acceptance of the idea that the early form of invasive cancer was a miniature of advanced cancer, i.e., a small cancer node in the stroma grew into the advanced form of invasive cancer.40