Elevated Putamen D ₂ Receptor Binding Potential in Major Depression With Motor Retardation: An [ ¹¹ C]Raclopride Positron Emission Tomography Study

Abstract

The results argue that extracellular dopamine is lower in subjects experiencing a major depressive episode that features motor retardation. This depression subtype should preferentially benefit from dopamine-increasing medications and should be targeted in future clinical trials of dopamine reuptake inhibitors.