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Synthesis of Collinin, an Antiviral Coumarin
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2003
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Medicinal ChemistryNatural Product SynthesisBioorganic ChemistryBiochemistryMedicineNatural SciencesAntiviral Drug DevelopmentVirologyOrganic ChemistryPropiolic AcidAntiviral DrugPharmacologyAntiviral CompoundPharmaceutical ChemistryDrug DiscoveryAntiviral Coumarin
Collinin (1), a geranyloxycoumarin, has been synthesized in three steps and 24.6% overall yield from pyrogallol (2) and propiolic acid (3).