Tranexamic Acid Is Effective in Decreasing Postoperative Bleeding and Transfusions in Primary Coronary Artery Bypass Operations

Abstract

In this randomized, placebo-controlled trial, we investigated the efficacy of tranexamic acid to decrease bleeding and blood transfusions after open-heart operations. Tranexamic acid administered before and during the operation was effective in decreasing both bleeding and transfusions. When tranexamic acid was administered immediately after the operation, it had a minor beneficial effect.