A Gene Cluster Encoding Rhizoxin Biosynthesis in “ <i>Burkholderia rhizoxina</i> ”, the Bacterial Endosymbiont of the Fungus <i>Rhizopus microsporus</i>

Abstract

Cloning, sequencing and gene analysis of the rhi gene locus in the genome of the rhizoxin-producing bacterial endosymbiont “Burkholderia rhizoxina” of the rice-pathogenic fungus Rhizopus microsporus provides the first insight into the giant trans-AT NRPS–PKS thiotemplate assembly line for the potent antimitotic macrolide.