Synapse · 2003 · 41 citations · 33 references
Life SciencesEndocrinologyNeuroscienceNeurochemistryNeuroendocrinologySteroid BiochemistryAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesMammalian EndocrinologyRodent EndocrinologyStress EndocrinologyAdrenal Cortex FunctionAdrenal Steroid ReceptorsArcuate NucleusGlucocorticoid HomeostasisGlucocorticoid MetabolismGlucocorticoid Receptor SignalingGlucocorticoid ReceptorsGlucocorticoid Signaling
In order to test for glucocorticoid regulation of CART in the arcuate nucleus, adrenalectomies (ADX) and hormone replacements (HRs) were carried out in groups of rats. CART mRNA levels were determined by in situ hybridization and CART peptide levels by immunocytochemistry. ADX caused a lowering of CART mRNA and peptides levels in the arcuate and this was reversed by HR. These results indicate a glucocorticoid regulation of CART in the arcuate. The regulation could be direct through an action of glucocorticoid receptors or indirectly through ADX-induced changes in leptin levels. These findings suggest a role for CART in the stress response.
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Hypothalamic CART is a new anorectic peptide regulated by leptin
Peter Lommer Kristensen, Martin E. Judge, Lars Thim et al. · Nature · 1998 · 1.3K citations
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
Carol F. Elias, Charlotte Lee, Joseph F. Kelly et al. · Neuron · 1998 · 799 citations · Full text