Protein-losing Enteropathy and Intestinal Bleeding

Abstract

Case Studies1 March 1966Protein-losing Enteropathy and Intestinal BleedingThe Role of Lymphatic-Venous ConnectionsJOHN D. DAVIDSON, M.D., EDWARD P. FLYNN, M.D., JOEL B. KIRKPATRICK, M.D.JOHN D. DAVIDSON, M.D.Search for more papers by this author, EDWARD P. FLYNN, M.D.Search for more papers by this author, JOEL B. KIRKPATRICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-628 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of protein-losing enteropathy has become well known since the first definitive demonstration that protein can be lost into the gut (1, 2). The now voluminous literature on this subject reveals that a variety of diseases can be associated with this phenomenon and that the pathogenetic mechanisms of protein loss are multiple.Intestinal lymphangiectasia as a cause of protein loss into the gut has been described by Waldmann and associates (3). In this condition dilated lacteals in the intestinal mucosa and dilated lymphatics in the mesentery are present, and the rupture of these thin-walled channels leads to protein loss....References1. STEINFELDDAVIDSONGORDON JLJDRS: Mechanism for hypoalbuminemia in patients with ulcerative colitis and regional enteritis (abstract). J. Clin. Invest. 36: 931, 1957. Google Scholar2. CITRINSTERLINGHALSTEAD YKJA: The mechanism of hypoproteinemia associated with giant hypertrophy of the gastric mucosa. New Eng. J. Med. 257: 906, 1957. CrossrefMedlineGoogle Scholar3. WALDMANNSTEINFELDDUTCHERDAVIDSONGORDON TAJLTFJDRS: The role of the gastrointestinal system in "idiopathic hypoproteinemia." 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Google Scholar22. GREENGEISLERERSLEV DPHAJ: Protein-losing enteropathy complicating prolonged bleeding in hemophilia. Ann. Intern. Med. 61: 928, 1964. LinkGoogle Scholar23. WALDMANN T: Macromolecular Aspects of Protein Absorption and Excretion in the Mammalian Intestine. Report of the 50th Ross Conference on Pediatric Research. Ross Laboratories, Columbus, Ohio. In press. Google Scholar24. STEINFELDDAVIDSONGORDONGREENE JLJDRSFE: The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis. Amer. J. Med. 29: 405, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN D. DAVIDSON, M.D.; EDWARD P. FLYNN, M.D.; JOEL B. KIRKPATRICK, M.D.Affiliations: St. Louis, MissouriFrom the Departments of Medicine and Pathology, Washington University School of Medicine, and the Department of Medicine, St. Louis University School of Medicine, St. Louis, Mo.Requests for reprints should be addressed to John D. Davidson, M.D., 5505 Delmar Blvd., St. Louis, Mo. 63112. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySticky Situation: Bleeding Duodenal Lymphangiectasias Treated with Lymphatic Glue EmbolizationSteroid-Refractory Protein-Losing Enteropathy with Gastrointestinal Bleeding in a Patient with Fontan CirculationProtein-Losing EnteropathiesIntestinal Lymphangiectasia Causing Massive Gastrointestinal BleedA case of recurrent gastrointestinal bleeding and protein-losing gastroenteropathyAcute gastrointestinal bleeding from focal duodenal lymphangiectasiaProtein-Losing EnteropathiesBleeding from duodenal lymphangiectasia.Intestinal lymphangiectasia associated with fatal gastrointestinal bleeding 1 March 1966Volume 64, Issue 3 Page: 628-635 Keywords Anemia Edema Enteropathies Hemorrhage Mucous membranes Pathogens Proteins ePublished: 1 December 2008 Issue Published: 1 March 1966 PDF downloadLoading ...