A New Translocation Syndrome (3/B)

Abstract

A NEW familial syndrome associated with a translocation between a chromosome No. 3 and a member of the B group (No. 4–5) is described in this report. Among the many family members, 6 infants were discovered with a similar pattern of congenital anomalies. The congenitally abnormal children and numerous miscarriages were presumably associated with the unbalanced translocation state, which was transmitted by the female but not the male carrier parents. This differential transmission was similar to that described by Hamerton et al.1 for Down's syndrome (mongolism) associated with a familial 13–15/21 (D/G) translocation.Case ReportThe propositus (V-32, Fig. 1) was . . .