Endothelial nitric oxide synthase is downregulated during hyperdynamic sepsis

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

Andy Petros, David Bennett, Patrick Vallance · The Lancet · 1991 · 871 citations

Veterinary Medicine, Critical Care Nursing, Critical Care Pharmacology +13

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

M Yoshizumi, Mark A. Perrella, J. C. Burnett et al. · Circulation Research · 1993 · 776 citations · Full text

Life Sciences, Cardiology, Molecular Biology +7

Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat

Richard G. Knowles, Mark Salter, Steve Brooks et al. · Biochemical and Biophysical Research Communications · 1990 · 387 citations

Life Sciences, Immunology, Pharmacology +12

The Complex Pattern of Cytokines in Sepsis Association Between Prostaglandins, Cachectin, and Interleukins

Wolfgang Ertel, Mary H. Morrison, Ping Wang et al. · Annals of Surgery · 1991 · 250 citations

Veterinary Medicine, Immunology, Pathobiology +17

Evidence of increased nitric oxide production in patients with the sepsis syndrome.

Tom Evans, A Carpenter, H Kinderman et al. · PubMed · 1993 · 223 citations

Veterinary Medicine, Physiology, Surgery +11