Protective role of pigment epithelium‐derived factor (PEDF) in early phase of experimental diabetic retinopathy

Abstract

Results suggest that PEDF could prevent neuronal derangements and vascular hyperpermeability in early diabetic retinopathy via inhibition of NADPH oxidase-driven oxidative stress generation. Substitution of PEDF may offer a promising strategy for halting the development of diabetic retinopathy.