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Therapeutic activity of the topoisomerase I inhibitor J-107088 [6- N -(1-hydroxymethyla-2-hydroxy) ethylamino-12,13-dihydro-13-(β- D -gluco pyranosyl)- 5H -indolo[2,3- a ]-pyrrolo[3,4- c ]-carbazole-5,7( 6H )-dione] against pediatric and adult central nervous system tumor xenografts

Neuro-oncologyMedicineTherapeutic ActivityPharmacological AgentPharmacotherapyAnti-cancer AgentDrug DevelopmentPharmacologyRadiation OncologyInhibitory ActivityTumor BiologyDrug Discovery