Variations in the Chromatographic Properties of Different Silica Gel Samples

Abstract

Silica gels for adsorption chromatography differ widely in their performance, depending upon the nature of the starting silica and its subsequent treatment. A general theory of the origin of these differences (and their control) is proposed in terms of the structure of the silica surface. Variations in the activity, selectivity, and linear capacity of different silica samples are readily understandable in terms of this theory. Details are provided for the initial evaluation, optimum treatment (activation and deactivation), and final standardization of silica adsorbents.