Elucidating the Role of Interleukin 1β and Prostaglandin E2 in Upper Airway Mucosal Wound Healing

Abstract

Mucosal injury is associated with up-regulation of inflammatory genes and parallel increases in secretion levels of IL-1beta and PGE2, key mediators of inflammation and healing. Subglottic mucosal fibroblasts are a potential source of inflammatory mediators after injury or other trauma.