FEBS Letters · 1995 · 105 citations · 16 references
Life SciencesBiotechnologyImmunologyMolecular VirologyVaccinologyVirologyAntigen PresentationViral InfectionsVirus-host InteractionsAntigen Presentation In Viral InfectionAntiserum PreparationAntiviral PeptidesParticle Surface PropertiesProcessing Of Viral AntigensViral Antigen RecognitionVirus-like Particle Antigen PresentationVirus-like Particle Engineering
By using a new tobacco mosaic virus (TMV) vector [Hamamoto, H., et al. (1993) Bio/Technology 11, 930-932], we have constructed TMV particles which present three different kinds of epitopes, two of them from influenza virus hemagglutinin (HA), and one from human immunodeficiency virus type I (HIV-I) envelope protein, on the surface of the particles. Each of these TMV particles reacted with each anti-peptide antiserum. These results suggest that this TMV vector can be used as an antigen presentation system.
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