Immunophenotypic analysis of the p53 gene in non‐melanoma skin cancer and correlation with apoptosis and cell proliferation

Abstract

p53 immunoreactivity was high in the majority of the skin carcinomas examined and correlated positively with cell proliferation and negatively with apoptosis. The p53 protein overexpression appears to be related to an inactivated protein resulting from mutations of the p53 gene or other unclear molecular mechanisms.