Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

Takashi Tsuruo, Harumi Iida, Shigeru Tsukagoshi et al. · PubMed · 1981 · 1.5K citations

Medicine, Oncology, Pharmacology +7

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

Caroline E. Grant, Gunnar Valdimarsson, David R. Hipfner et al. · PubMed · 1994 · 635 citations

Medicine, Cancer Biology, Oncology +16

Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene.

Gary D. Kruh, Andrew M. Chan, Kenneth A. Myers et al. · PubMed · 1994 · 120 citations

Medicine, Molecular Biology, Oncology +15

Resistance to diverse apoptotic triggers in multidrug resistant HL60 cells and its possible relationship to the expression of P-glycoprotein, Fas and of the novel anti-apoptosis factors IAP (inhibitory of apoptosis proteins)

Monica Notarbartolo, Melchiorre Cervello, Luisa Dusonchet et al. · Cancer Letters · 2002 · 92 citations

Life Sciences, Cell Biology, Oncology +17

Multidrug resistance-associated protein subfamily transporters and drug resistance.

Michihiko Kuwano, S. Toh, Takeshi Uchiumi et al. · PubMed · 1999 · 79 citations

Medicine, Oncology, Pharmacology +17