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A Highly Enantioselective Synthesis of 2-Substituted Malates by Asymmetric Aldol Reaction
23
Citations
8
References
1989
Year
Asymmetric CatalysisEnantioselective SynthesisEngineeringBiochemistryNatural SciencesOrganic ChemistryHighly Enantioselective SynthesisChiral DiamineChemistryAsymmetric Aldol ReactionStereoselective SynthesisPharmacologyChiral PromoterSynthetic Chemistry2-Substituted MalatesBiomolecular Engineering
Abstract In the presence of a chiral promoter consisted of chiral diamine coordinated tin(II) triflate and tributyltin fluoride, silyl enol ether of S-ethyl ethanethioate reacts with α-ketoesters to afford the corresponding aldol-type adducts, 2-substituted malates, in good yields with excellent enantiomeric excesses.
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