A new route to 1,2,4‐ triazoles and 1,3,4‐ thiadiazoles from 1‐acylbithiourea

Abstract

Abstract The intramolecular cyclization of 1‐ acylbithiourea 1 gave 1,2,4‐triazole 2 and 1,3,4‐thiadiazole 3 . The reaction of 1 with p ‐toluenesulfonyl chloride in the presence of trithylamine afforded 3 . Treatment of 1 with methyl iodide in the absence of any base yielded 2‐methylthio‐1,3,4‐thiadiazole 10 and 2‐imino‐ 1,3,4‐thiadiazoline 12 .