Altered Thiol and Calcium Homeostasis in Oxidative Hepatocellular Injury

Abstract

Perturbation of cellular thiol homeostasis occurs during the early phase of oxidative cell injury in isolated hepatocytes. This perturbation, involves depletion of soluble and protein-bound thiols, and is associated with altered intracellular calcium (Ca") homeostasis resulting from inhibition of major Ca2+ transport systems. The result is sustained increase in cytosolic Ca2+ concentration which appears to trigger cytotoxicity.