Concepedia

A methotrexate insensitive variant of folate reductase present in two lines of methotrexate-resistant L5178Y cells

J.H. Goldie, Gerald Krystal, D Hartley, G Gudauskas, Shoukat Dedhar

European Journal of Cancer (1965) · 1980 · 61 citations · 16 references

DOI

Concepts

References

16

The Determination of Enzyme Dissociation Constants

Hans Lineweaver, Dean Burk · Journal of the American Chemical Society · 1934 · 12.1K citations

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The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

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Gene Amplification and Drug Resistance in Cultured Murine Cells

Robert Schimke, Randal J. Kaufman, F W Alt et al. · Science · 1978 · 322 citations

, , +17

Defective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells

Glenn A. Fischer · Biochemical Pharmacology · 1962 · 168 citations

, , +11

Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells

G.A. Fischer · Biochemical Pharmacology · 1961 · 150 citations

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