Neuroendocrinology · 2008 · 39 citations · 0 references
MedicineEndocrinologyNeuroscienceNeuroendocrinologyReproductive EndocrinologyReproductive PhysiologyGonadal HormonesHormonal Regulation Of ReproductionHypothalamic-pituitary RegulationHypothalamic-pituitary-gonadal AxisReproductive NeuroendocrinologyRodent EndocrinologyDevelopmental Hormonal EffectsEndocrine Control Of SteroidogenesisEstradiol PhysiologyEstrus BehaviorHormonal Indicators Of EstrusHypothalamic-pituitary-gonadal Axis RegulationOvarian Hormonal FeedbackSex Steroid Physiology
In female rats treated with 100 µg estradiol benzoate on the first day of life, the following data were obtained in adult or juvenile life: (1) predominance of vaginal estrus; (2) significantly enhanced male and completely suppressed female sexual behavior associated with an increased ‘attractiveness’ to the male test partners; (3) hypogonadotrophic hypogonadism; (4) sterility; (5) a significant increase of postpuberal body growth; and (6) non-evocability of the ‘positive estrogen feedback effect’. These findings are explained by a paradoxical influence of estrogen on the organization of the hypothalamus.