An Unprecedented Silver Salt Effect Switches the Facial Selectivity in the Vinylogous Mukaiyama Aldol Reaction

Abstract

Abstract Silver hexafluroantimonate was identified as a highly efficient agent to reverse the facial selectivity of the titanium chloride‐mediated vinylogous Mukaiyama aldol reaction (VMAR), and this unprecedented reaction provides a concise, diastereoselective synthesis of δ‐hydroxy‐α,γ‐dimethyl‐α,β‐unsaturated carbonyl units from readily available chiral vinylketene silyl N , O ‐acetal 6 and ethyl glyoxylate 8 .