The anti‐inflammatory effect of cyclooxygenase inhibitors in fibroblast‐like synoviocytes from the human temporomandibular joint results from the suppression of <scp>PGE2</scp> production

Abstract

The COX inhibitors indomethacin and celecoxib reduce the expression of inflammatory factors, such as COX-2 and IL-6, in FLS from the TMJ via suppression of PGE2 production. EP2 and EP4 were the main receptors for PGE2 present in the FLS. The approach used in this study may be useful for revealing how drugs such as NSAIDs affect the cellular functions of FLS from the TMJ.