Optimized conditions of bio-mimetic artificial membrane permeation assay

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 2.2K citations

Life Sciences, Cell Biology, Oncology +14

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Per Artursson, Johan Karlsson · Biochemical and Biophysical Research Communications · 1991 · 1.9K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Physicochemical High Throughput Screening:  Parallel Artificial Membrane Permeation Assay in the Description of Passive Absorption Processes

Manfred Kansy, Frank Senner, Klaus Gubernator · Journal of Medicinal Chemistry · 1998 · 1.3K citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

Shinji Yamashita, Tomoyuki Furubayashi, Makoto Kataoka et al. · European Journal of Pharmaceutical Sciences · 2000 · 565 citations

Pharmacy, Pharmaceutics, Pharmacology +14

Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

Susanne Winiwarter, Nicholas M. Bonham, Fredrik Ax et al. · Journal of Medicinal Chemistry · 1998 · 452 citations

Pharmacy, Pharmacokinetics, Pharmacology +17