Gold‐Catalyzed Intramolecular Oxidative Cross‐Coupling of Nonactivated Arenes

Abstract

An (Au)some coupling! Gold-catalyzed cascade CO cyclizations of benzyl-substituted allenoate esters followed by intramolecular oxidative CC cross-coupling involving aryl CH functionalization were performed with Selectfluor as the oxidant (see scheme). This operationally simple and mild procedure benefits from complete axis-to-center chirality transfer and allows for the preparation of surprisingly uncommon tricyclic motifs.