The novel<scp>CGRP</scp>receptor antagonist<scp>BIBN</scp>4096<scp>BS</scp>alleviates a postoperative intestinal inflammation and prevents postoperative ileus

Abstract

CGRP is immediately released during abdominal surgery and induces a neurogenic inflammation via activation of abdominal macrophages. BIBN4096BS prevented IM-induced inflammation and restored GI motility. These findings suggest that CGRP receptor antagonism could be instrumental in the prevention of POI.