Propranolol in Patients with Angina Pectoris

Abstract

Article1 December 1967Propranolol in Patients with Angina PectorisRALPH E. GIANELLY, M.D., ROBERT H. GOLDMAN, M.D., BERNARD TREISTER, M.D., DONALD C. HARRISON, M.D.RALPH E. GIANELLY, M.D., ROBERT H. GOLDMAN, M.D., BERNARD TREISTER, M.D., DONALD C. HARRISON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1216 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral studies have indicated that propranolol (1-(isopropylamino)-3-(1-naphthyloxy)-2-propranol) hydrochloride, a beta-adrenergic blocking drug, may be useful in the treatment of angina pectoris. The drug has been reported to reduce the frequency and severity of chest pain and to increase exercise tolerance (1-3). Although it appears that propranolol may be helpful in the management of some patients with angina pectoris, it has been impossible to predict which patients will be helped. A simple test to separate a priori those patients who would respond to propranolol from those who would not would be very valuable to clinicians since the drug may have major...References1. HAMERGRANDJEANMELENDEZSOWTON JTLGE: Effect of propranolol (Inderal) in angina pectoris: preliminary report. Brit. Med. J. 2: 720, 1964. CrossrefMedlineGoogle Scholar2. GILLAMPRICHARD PMBN: Use of propranolol in angina pectoris. Brit. Med. J. 2: 337, 1965. CrossrefMedlineGoogle Scholar3. GINNORGAIN WMES: Propranolol hydrochloride in the treatment of angina pectoris, JAMA 198: 1214, 1966. CrossrefMedlineGoogle Scholar4. KRASNOWROLETTYURCHAKHOODGORLIN NELPMWBR: Isoproterenol and cardiovascular performance. Amer. J. Med. 37: 514, 1964. CrossrefMedlineGoogle Scholar5. EPSTEINROBINSONKAHLERBRAUNWALD SBRLE: Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest. 44: 1745, 1965. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAuthors: RALPH E. GIANELLY, M.D.; ROBERT H. GOLDMAN, M.D.; BERNARD TREISTER, M.D.; DONALD C. HARRISON, M.D.Affiliations: Palo Alto, CaliforniaFrom the Cardiology Division, Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif.This study was supported by grants HE-09058-03 and ITL HE-05709-01, National Heart Institute, National Institutes of Health, Bethesda, Md., and grant FR-70, General Clinical Research Grants Branch, U. S. Public Health Service, Washington, D. C.At the time of this study Dr. Gianelly was a Research Fellow in the Cardiology Division, Department of Medicine, Stanford University School of Medicine.Requests for reprints should be addressed to Donald C. Harrison, M.D., Chief, Cardiology Division, Stanford University Medical Center, Palo Alto, Calif. 94305. 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REIS, M.D., EDWARD B. STINSON, M.D.Exercise tolerance in patients with angina pectorisDiagnostic and Therapeutic Aspects of Stable Angina PectorisCoronary flow changes and cardiac adrenergic blockade during nitroglycerin infusionsHuman Cardiovascular Effects of Alprenolol, A Beta‐Adrenergic Blocker: Hemodynamic, Antiarrhythmic, and Antianginalβ-ReceptorenblockerTherapy of Angina Pectoris with Propranolol and Long-Acting NitratesThe effect of propranolol on exercise-induced ischemic S-T segment depressionBeta-adrenergic blocking agents for the treatment of angina pectorisBeta-blockade and angina pectoris: a controlled multi-centre clinical trialPropranolol Combined with Isosorbide Dinitrate versus Placebo in Angina PectorisNew Drugs in the Treatment of AnginaPROPRANOLOL IN ANGINA PECTORISEffects of Propranolol and Isosorbide Dinitrate on Exercise Performance and Adrenergic Activity in Patients with Angina PectorisChronic beta adrenergic receptor blockade in the treatment of idiopathic hypertrophic subaortic stenosisInhibition of the Adrenergic Nervous System in the Treatment of Angina PectorisChapter 8 Angina Pectoris and Antianginal Agents 1 December 1967Volume 67, Issue 6Page: 1216-1225KeywordsAnginaDrugsExerciseHeartIschemiaLongitudinal studiesMedical servicesResearch grants ePublished: 1 December 2008 Issue Published: 1 December 1967 PDF downloadLoading ...