Targeting and Uptake of Multilayered Particles to Colorectal Cancer Cells

Abstract

Core/shell particles and capsules formed by a layer-by-layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2006/c0564_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.