Fundus Autofluorescence in the<i>Abca4^−/−</i>Mouse Model of Stargardt Disease—Correlation With Accumulation of A2E, Retinal Function, and Histology

Abstract

Fundus AF can be used to monitor lipofuscin accumulation and melanin-related changes in vivo in mouse models of retinal disease. High RPE lipofuscin may not adversely affect retinal structure or function over prolonged time intervals, and melanin-related changes (melanolipofuscin formation) may occur before the decline in retinal function.